Evolutionary conservation scores from SiPhy, PhyloP, PhastCons and GERP++.Functional impact predictions from Sorting Intolerant from Tolerant (SIFT), MutationTaster, and the Likelihood Ratio Test (LRT).1000 Genomes Project and the Exome Sequencing Project (ESP).Mastermind, the comprehensive database of genomic literature from Genomenon, providing access to NGS variant data from millions of PubMed publications.The annotation information comes from several sources, including: Annotations include information about the frequency of the variant in the general population, in specific populations, and in publications, as well as information concerning the variant’s impact on functionality. Handling large volumes of data is what Lasergene Genomics was designed to do – let us do the heavy lifting, so you can focus on the results.įor human resequencing data, DNASTAR provides access to the Variant Annotation Database, which contains variant information using coordinates from GRCh37 (hg19) and GRCh38. Advanced gene filtering offers the ability to determine the level of disruption to each gene caused by variations. Comprehensive post-assembly analysis options make it easy to identify and compare genetic variants as well as structural and non-coding variants. Lasergene Genomics enables you to align resequencing data from all major NGS platforms against a reference sequence with unsurpassed ease and speed. Whether you are working with whole genome, whole exome, or other targeted sequencing data, the resulting amount of information requires a significant amount of data processing and analysis. The sheer volume of data generated from whole exome sequencing and whole genome sequencing presents a challenge for many researchers faced with the prospect of assembling and analyzing it. Let Lasergene Genomics do the heavy lifting of whole genome and whole exome sequencing analysis so you can focus on the results.